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Using a dose‐finding benchmark to quantify the loss incurred by dichotomization in Phase II dose‐ranging studies Early View

  • Journal: Biometrical Journal
  • Authors: Pavel Mozgunov, Thomas Jaki, Xavier Paoletti
  • Published Date: Jun 12, 2020

Abstract While there is recognition that more informative clinical endpoints can support better decision‐making in clinical trials, it remains a common practice to categorize endpoints originally...

Measuring intrarater association between correlated ordinal ratings Early View

  • Journal: Biometrical Journal
  • Authors: Kerrie P. Nelson, Thomas J. Zhou, Don Edwards
  • Published Date: Jun 12, 2020

Abstract Variability between raters' ordinal scores is commonly observed in imaging tests, leading to uncertainty in the diagnostic process. In breast cancer screening, a radiologist visually...

Variable selection with P‐splines in functional linear regression: Application in graft‐versus‐host disease Early View

  • Journal: Biometrical Journal
  • Authors: M. Carmen Aguilera‐Morillo, Ismael Buño, Rosa E. Lillo, Juan Romo
  • Published Date: Jun 10, 2020

Abstract This paper focuses on the problems of estimation and variable selection in the functional linear regression model (FLM) with functional response and scalar covariates. To this end, two...

A pseudo‐likelihood method for estimating misclassification probabilities in competing‐risks settings when true‐event data are partially observed Early View

  • Journal: Biometrical Journal
  • Authors: Philani B. Mpofu, Giorgos Bakoyannis, Constantin T. Yiannoutsos, Ann W. Mwangi, Margaret Mburu
  • Published Date: Jun 10, 2020

Abstract Outcome misclassification occurs frequently in binary‐outcome studies and can result in biased estimation of quantities such as the incidence, prevalence, cause‐specific hazards, cumulative...

Climate change impacts on Australia's eucalypt and coral species: Comparing and sharing knowledge across disciplines Early View

  • Journal: Wiley Interdisciplinary Reviews: Climate Change
  • Authors: Trevor H. Booth, Paul R. Muir
  • Published Date: Jun 10, 2020

Abstract Two of Australia's most iconic ecosystems have recently sustained heavy damage related to climatic changes: the extensive eucalypt forests from catastrophic bushfires and the Great Barrier...

Sequencing and imputation in GWAS: Cost‐effective strategies to increase power and genomic coverage across diverse populations Early View

  • Journal: Genetic Epidemiology
  • Authors: Corbin Quick, Pramod Anugu, Solomon Musani, Scott T. Weiss, Esteban G. Burchard, Marquitta J. White, Kevin L. Keys, Francesco Cucca, Carlo Sidore, Michael Boehnke, Christian Fuchsberger
  • Published Date: Jun 10, 2020

Abstract A key aim for current genome‐wide association studies (GWAS) is to interrogate the full spectrum of genetic variation underlying human traits, including rare variants, across populations....

A flexible two‐dimensional basic warranty policy with two continuous warranty regions Early View

  • Journal: Quality and Reliability Engineering International
  • Authors: Rui Zheng, Chun Su
  • Published Date: Jun 09, 2020

Abstract Flexible warranty policies can satisfy customers by allowing them to select the warranty regions according to their usage rates. However, customers are usually unaware of their future usage...

Deep learning: Computational aspects Early View

  • Journal: WIREs Computational Statistics
  • Authors: Vadim Sokolov, Nicholas Polson
  • Published Date: Jun 09, 2020

Abstract In this article, we review computational aspects of deep learning (DL). DL uses network architectures consisting of hierarchical layers of latent variables to construct predictors for...

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