Statistics in Medicine

Table of Contents

Volume 17 Issue 15‐16 (15 ‐ 30 August 1998)

1661-1892

Preface

Preface

  • Author: Byron Jones
  • Pub Online: Dec 21, 1998
  • DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1661::AID-SIM968>3.0.CO;2-2 (p 1661-1661)

Research Articles

Statistical shortcomings in licensing applications

  • Author: John A. Lewis, Karen M. Facey
  • Pub Online: Dec 21, 1998
  • DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1663::AID-SIM969>3.0.CO;2-U (p 1663-1673)

Methodological advances and plans for improving regulatory success for confirmatory studies

  • Author: Gary G. Koch, Sonia M. Davis, Randy L. Anderson
  • Pub Online: Dec 21, 1998
  • DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1675::AID-SIM970>3.0.CO;2-C (p 1675-1690)

Practical issues in equivalence trials

  • Author: A. F. Ebbutt, L. Frith
  • Pub Online: Dec 21, 1998
  • DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1691::AID-SIM971>3.0.CO;2-J (p 1691-1701)

Therapeutic equivalence investigations: statistical considerations

  • Author: Joachim Röhmel
  • Pub Online: Dec 21, 1998
  • DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1703::AID-SIM972>3.0.CO;2-G (p 1703-1714)

Issues for statisticians in pharmaco‐economic evaluations

  • Author: A. P. Grieve
  • Pub Online: Dec 21, 1998
  • DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1715::AID-SIM973>3.0.CO;2-6 (p 1715-1723)

A forecasting approach to accelerate drug development

  • Author: C. Anthony Hunt, Serge Guzy, Daniel L. Weiner
  • Pub Online: Dec 21, 1998
  • DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1725::AID-SIM974>3.0.CO;2-2 (p 1725-1740)

Discussions

Discussion

  • Author: Jorgen Seldrup
  • Pub Online: Dec 21, 1998
  • DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1741::AID-SIM975>3.0.CO;2-9 (p 1741-1743)

Research Articles

Counts and times to events

  • Author: J. K. Lindsey
  • Pub Online: Dec 21, 1998
  • DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1745::AID-SIM976>3.0.CO;2-V (p 1745-1751)

Some controversies in planning and analysing multi‐centre trials

  • Author: Stephen Senn
  • Pub Online: Dec 21, 1998
  • DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1753::AID-SIM977>3.0.CO;2-X (p 1753-1765)

A comparison of various estimators of a treatment difference for a multi‐centre clinical trial

  • Author: B. Jones, D. Teather, J. Wang, J. A. Lewis
  • Pub Online: Dec 21, 1998
  • DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1767::AID-SIM978>3.0.CO;2-H (p 1767-1777)

Multi‐centre trial analysis revisited

  • Author: A. Lawrence Gould
  • Pub Online: Dec 21, 1998
  • DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1779::AID-SIM979>3.0.CO;2-7 (p 1779-1797)

Discussions

Discussion

  • Author: Peter R. Freeman
  • Pub Online: Dec 21, 1998
  • DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1799::AID-SIM980>3.0.CO;2-V (p 1799-1800)

Research Articles

The management of interim analyses in drug development

  • Author: Karen M. Facey, John A. Lewis
  • Pub Online: Dec 21, 1998
  • DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1801::AID-SIM981>3.0.CO;2-L (p 1801-1809)

Discussions

Discussion

  • Author: John Whitehead
  • Pub Online: Dec 21, 1998
  • DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1811::AID-SIM982>3.0.CO;2-H (p 1811-1812)
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