Statistics in Medicine

Table of Contents

Volume 23 Issue 16 (30 August 2004)


Research Articles

Quantile estimation following non‐parametric phase I clinical trials with ordinal response

  • Author: Ranjan K. Paul, William F. Rosenberger, Nancy Flournoy
  • Pub Online: Jul 27, 2004
  • DOI: 10.1002/sim.1834 (p 2483-2495)

A general statistical principle for changing a design any time during the course of a trial

  • Author: Hans‐Helge Müller, Helmut Schäfer
  • Pub Online: Jul 27, 2004
  • DOI: 10.1002/sim.1852 (p 2497-2508)

A new approach to modelling interactions between treatment and continuous covariates in clinical trials by using fractional polynomials

  • Author: Patrick Royston, Willi Sauerbrei
  • Pub Online: Jul 27, 2004
  • DOI: 10.1002/sim.1815 (p 2509-2525)

A measurement error model with a Poisson distributed surrogate

  • Author: Liang Li, Mari Palta, Jun Shao
  • Pub Online: Jul 27, 2004
  • DOI: 10.1002/sim.1838 (p 2527-2536)

On sample size for sensitivity and specificity in prospective diagnostic accuracy studies

  • Author: Jialiang Li, Jason Fine
  • Pub Online: Jul 27, 2004
  • DOI: 10.1002/sim.1836 (p 2537-2550)

A sample size computation method for non‐linear mixed effects models with applications to pharmacokinetics models

  • Author: Dongwoo Kang, Janice B. Schwartz, Davide Verotta
  • Pub Online: Jul 27, 2004
  • DOI: 10.1002/sim.1695 (p 2551-2566)

Validation and updating of predictive logistic regression models: a study on sample size and shrinkage

  • Author: Ewout W. Steyerberg, Gerard J. J. M. Borsboom, Hans C. van Houwelingen, Marinus J. C. Eijkemans, J. Dik F. Habbema
  • Pub Online: Jul 27, 2004
  • DOI: 10.1002/sim.1844 (p 2567-2586)

A simple significance test for quantile regression

  • Author: David T. Redden, José R. Fernández, David B. Allison
  • Pub Online: Jul 27, 2004
  • DOI: 10.1002/sim.1839 (p 2587-2597)

Book Reviews



  • Author:
  • Pub Online: Jul 27, 2004
  • DOI: 10.1002/sim.1950 (p 2624-2624)

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