Biometrical Journal

Table of Contents

Volume 48 Issue 4 (August 2006)

487-737

Contents

Contents: Biom. J. 4/2006

  • Author:
  • Pub Online: Aug 08, 2006
  • DOI: 10.1002/bimj.200690003 (p 487-489)

Editorial

Editorial – Adaptive Designs: Expectations are High

  • Author: Joachim Röhmel
  • Pub Online: Aug 08, 2006
  • DOI: 10.1002/bimj.200610257 (p 491-492)

Reviews

Application of Adaptive Designs – a Review

  • Author: P. Bauer, J. Einfalt
  • Pub Online: May 10, 2006
  • DOI: 10.1002/bimj.200510204 (p 493-506)

An Overview of Statistical Approaches for Adaptive Designs and Design Modifications

  • Author: Helmut Schäfer, Nina Timmesfeld, Hans‐Helge Müller
  • Pub Online: Aug 08, 2006
  • DOI: 10.1002/bimj.200510234 (p 507-520)

Flexible Designs by Adaptive Plans of Generalized Pocock‐ and O'Brien‐Fleming‐Type and by Self‐Designing Clinical Trials

  • Author: Joachim Hartung
  • Pub Online: Jun 13, 2006
  • DOI: 10.1002/bimj.200510212 (p 521-536)

Sample Size Recalculation in Internal Pilot Study Designs: A Review

  • Author: Tim Friede, Meinhard Kieser
  • Pub Online: Jul 25, 2006
  • DOI: 10.1002/bimj.200510238 (p 537-555)

Some Aspects of the Application of Internal Pilot Studies

  • Author: Peter A. Lachenbruch, Janet Wittes
  • Pub Online: Aug 08, 2006
  • DOI: 10.1002/bimj.200610243 (p 556-557)

Rejoinder

  • Author: Tim Friede, Meinhard Kieser
  • Pub Online: Jul 25, 2006
  • DOI: 10.1002/bimj.200610252 (p 558-558)

Regulatory Perspectives

FDA's Critical Path Initiative: A Perspective on Contributions of Biostatistics

  • Author: R. T. O'Neill
  • Pub Online: Jul 25, 2006
  • DOI: 10.1002/bimj.200510237 (p 559-564)

A Regulatory View on Adaptive/Flexible Clinical Trial Design

  • Author: H. M. James Hung, Robert T. O'Neill, Sue‐Jane Wang, John Lawrence
  • Pub Online: Jun 13, 2006
  • DOI: 10.1002/bimj.200610229 (p 565-573)

Confirmatory Clinical Trials with an Adaptive Design

  • Author: Armin Koch
  • Pub Online: Jul 25, 2006
  • DOI: 10.1002/bimj.200510239 (p 574-585)

Adaptive Designs from the Viewpoint of an Academic Biostatistician

  • Author: Helmut Schäfer
  • Pub Online: Aug 08, 2006
  • DOI: 10.1002/bimj.200610246 (p 586-590)

Challenges in Implementing Adaptive Designs: Comments on the Viewpoints Expressed by Regulatory Statisticians

  • Author: Paul Gallo, Willi Maurer
  • Pub Online: Aug 08, 2006
  • DOI: 10.1002/bimj.200610250 (p 591-597)

Opening the Adaptive Toolbox

  • Author: Janet Wittes, Peter A. Lachenbruch
  • Pub Online: Aug 08, 2006
  • DOI: 10.1002/bimj.200610240 (p 598-603)

A Consultant's Perspective on the Regulatory Hurdles to Adaptive Trials

  • Author: Cyrus R. Mehta, Yannis Jemiai
  • Pub Online: Aug 08, 2006
  • DOI: 10.1002/bimj.200610249 (p 604-608)
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