Statistics in Medicine

Two‐stage meta‐analysis of survival data from individual participants using percentile ratios

Journal Article

  • Author(s): Jessica K. Barrett, Vern T. Farewell, Fotios Siannis, Jayne Tierney, Julian P. T. Higgins
  • Article first published online: 23 Jul 2012
  • DOI: 10.1002/sim.5516
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Methods for individual participant data meta‐analysis of survival outcomes commonly focus on the hazard ratio as a measure of treatment effect. Recently, Siannis et al. (2010, Statistics in Medicine 29:3030–3045) proposed the use of percentile ratios as an alternative to hazard ratios. We describe a novel two‐stage method for the meta‐analysis of percentile ratios that avoids distributional assumptions at the study level. Copyright © 2012 John Wiley & Sons, Ltd.

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