Statistics in Medicine

A Bayesian subgroup analysis with a zero‐enriched Polya Urn scheme

Journal Article

Abstract

We introduce a new approach to inference for subgroups in clinical trials. We use Bayesian model selection, and a threshold on posterior model probabilities to identify subgroup effects for reporting. For each covariate of interest, we define a separate class of models, and use the posterior probability associated with each model and the threshold to determine the existence of a subgroup effect. As usual in Bayesian clinical trial design we compute frequentist operating characteristics, and achieve the desired error probabilities by choosing an appropriate threshold(s) for the posterior probabilities. Copyright © 2010 John Wiley & Sons, Ltd.

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