Statistics in Medicine

One‐sample aggregate data meta‐analysis of medians

Journal Article

An aggregate data meta‐analysis is a statistical method that pools the summary statistics of several selected studies to estimate the outcome of interest. When considering a continuous outcome, typically each study must report the same measure of the outcome variable and its spread (eg, the sample mean and its standard error). However, some studies may instead report the median along with various measures of spread. Recently, the task of incorporating medians in meta‐analysis has been achieved by estimating the sample mean and its standard error from each study that reports a median in order to meta‐analyze the means. In this paper, we propose two alternative approaches to meta‐analyze data that instead rely on medians. We systematically compare these approaches via simulation study to each other and to methods that transform the study‐specific medians and spread into sample means and their standard errors. We demonstrate that the proposed median‐based approaches perform better than the transformation‐based approaches, especially when applied to skewed data and data with high inter‐study variance. Finally, we illustrate these approaches in a meta‐analysis of patient delay in tuberculosis diagnosis.

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Published features on are checked for statistical accuracy by a panel from the European Network for Business and Industrial Statistics (ENBIS)   to whom Wiley and express their gratitude. This panel are: Ron Kenett, David Steinberg, Shirley Coleman, Irena Ograjenšek, Fabrizio Ruggeri, Rainer Göb, Philippe Castagliola, Xavier Tort-Martorell, Bart De Ketelaere, Antonio Pievatolo, Martina Vandebroek, Lance Mitchell, Gilbert Saporta, Helmut Waldl and Stelios Psarakis.