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Cost-effectiveness analysis under multiple effectiveness outcomes: A probabilistic approach. Statistics in Medicine. 2023; 1– 20. doi: 10.1002/sim.9841, , .
The economic evaluation of a new treatment is decisive in determining resource allocation between that treatment and a competing intervention. The criteria and analysis used to facilitate such evaluations are of emerging importance when there are priorities and multiple outcomes in the decision-making process.
In this work, probability-based criteria are developed to assess the cost-effectiveness of a new treatment compared to a standard treatment in the presence of a cost outcome and multiple measures of effectiveness. The proposed probability metrics quantify cost-effectiveness and incorporate policy maker priorities. Additionally, the criteria can be tailored to include relevant thresholds that may be required for cost-effectiveness evaluation. For example, a new treatment may need to provide a minimum gain in effectiveness compared to a standard treatment. Confidence limits are developed for the new probability criteria to determine if a new treatment is cost-effective.
The methodologies are illustrated on a study pertaining to the treatment of type two diabetes. Numerical and graphical results demonstrate the impact of thresholds on the probability of cost-effectiveness. The probability metrics are versatile as they may be modified for inclusion of different outcomes, priorities, and thresholds. These metrics and methods complement other evaluations, such as multi-criteria decision analysis.More Details